Cancer Biology and Therapeutics

Cancer genomics & metabolomics

Cancer genomics is the study of the totality of DNA sequence and gene expression differences between tumor cells and normal host cells. It aims to understand the genetic basis of tumor cell proliferation and the evolution of the cancer genome under mutation and selection by the body environment, the immune system and therapeutic interventions. The metabolites within a cell or biological system are being used to analyze cancer metabolism on a system-wide scale, painting a broad picture of the altered pathways and their interactions with each other. Cancer metabolomics involves chemical analysis by a range of analytical platforms through targeted/untargeted approaches. The application of metabolomics towards cancer research has led to a renewed appreciation of metabolism in cancer development and progression.